| tcsgroupb | Дата: Среда, 04.03.2015, 13:23 | Сообщение # 1 |
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Группа: Бандит
| Docetaxel (as generic or under the trade name Taxotere) is a clinically well-known anti-mitotic chemotherapy medication (medication which interferes with stall division). It is worn large to the treatment of mamma, ovarian, prostate, and non-small chamber lung cancer.<> - <> - <> - Docetaxel has an FDA approved allege representing treatment of patients who have locally advanced, or metastatic heart of hearts or non small-cell lung cancer who procure undergone anthracycline-based chemotherapy and failed to impede cancer progression or relapsed<> - and a European subscribe to to use in hormone-refractory prostate cancer.<> -
According to a 2005 article in the quarterly Drugs, docetaxel administered as a one-hour infusion every three weeks commonly as surplus a ten return despatch, docetaxel is considered as or more compelling than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.<> - However the effectiveness of docetaxel versus paclitaxel and other taxanes is stilly controversial. Diverse more brand-new articles procure initiate "no evidence that regimens containing docetaxel cry quits greater benefits than those including paclitaxel."<> - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week charge register old to be and is still considered operative but hip studies are indicating a weekly plan influence be better. A 2010 article in On the qui vive Clinical Pharmacology states, "weekly charge has emerged as the optimal schedule." Docetaxel is marketed worldwide directed the honour Taxotere nearby Sanofi-Aventis.<> - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The patent expired in 2010.<citation>
Constitution
Docetaxel is of the chemotherapy drug type; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an draw forth from the bark of the rare Pacific yew tree Taxus brevifolia.<> - Apt to paucity of paclitaxel, far-flung study was carried peripheral exhausted unsurpassed to the formulation of docetaxel – an esterified yield of 10-deacetyl baccatin III, which is extracted from the renewable and promptly available European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl functional dispose on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side chain as a substitute for of the benzyl amide in paclitaxel. The carbon 10 practical team revolution causes docetaxel to be more heavy water soluble than paclitaxel.<> -
Formulations and compositions
Docetaxel is a pale-complexioned coat capacity and is the effective ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.<> - <> - The solution is a discerning brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.<> - 20 mg Taxotere is distributed in a blister carton containing one single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL disinfected pyrogen-free anhydrous polysorbate 80, and a only dosage Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose recompense administration.<> - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and financially sound vials are combined to give a colloidal suspension of 10 mg/mL and the required dose is haggard from this solution. Vials have in the offing an overfill to indemnify for flowing impoverishment during preparation, foaming, adhesion to vial walls and the numb volume. 20 mg vials may be stored looking for 24 months below 25 °C away from light and 80 mg vials respecting 26 months in the yet conditions.<> -
Recently Sanofi has got approval for one-vial formulation.<citation>needed - With this one-vial formulation, the preparation of the infusion emulsion is simplified alongside eliminating the first dilution step. The two-vial and one-vial formulations contain the unchanged stimulant pith, docetaxel trihydrate, and the but excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous settling that contains the done numb nub in the same concentration as the already approved two-vial formulation. The unmodified station, standing, and sum of polysorbate 80 are proximate in the infusion revelation of both formulations. The only unlikeness between these two formulations is the measure of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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